EUSynBioS and Inscripta invite you to attend the webinar:

“A revolution in evolution: Using Inscripta’s Onyx™ Platform to ease and

enhance biological engineering”

Register here: https://register.gotowebinar.com/register/5134547092192371726

CRISPR has developed into a core tool to facilitate genome editing, inspiring transformative ideas in engineering biology. However, first-generation CRISPR technologies have been limited in scalability, accessibility, edit variety, and ease of use, restricting the potential of the technology. Inscripta’s automated platform addresses these limitations by combining easy-to-use and intuitive software with a push-button automated benchtop device, enabling high efficiency, massively parallel, precision-engineered edits to S. cerevisiae and E. coli genomes. In this webinar, we will present applications in E. coli that leverage this platform technology, showing how, in just a few weeks, a library totaling over 25,000 different edits and a separate library of 900 edits yield new biochemical insights underpinning tolerance to a panel of growth-inhibitory compounds. In another application of the Onyx technology, a saturation mutagenesis library was generated against the active site of an integrated GFP, with several engineered variants showing distinct intensity and spectral characteristics. These applications demonstrate the power of the Onyx platform to usher in a new era of genome editing.

Continuing our seminar series for the month of April, we have the pleasure to host Dr. Jasmin Hafner, currently a postdoctoral researcher at EAWAG, Switzerland. Jasmin will present her work conducted during her PhD at the Laboratory of Computational Systems Biotechnology at EPFL, Switzerland under the supervision of Prof. Vassily Hatzimanikatis and during her research stay at Stanford University, Stanford, CA, U.S.A. in collaboration with Prof. Christina Smolke. Their work was recently published in nature communications.

Registration is now open.

We are excited to resume the EUSynBioSeminar series in 2021! In the first seminar of the year, we have the pleasure to host PhD student Friederike Mey from Ghent University, Belgium. With Friederike, we will dive into the world of machine learning and learn how to harness it’s power for Synthetic Biology.

Registration is now open! Fill in the form here and join us on March 4th, 16.00 CET.

This month, EUSynBioS introduced a new seminar series with a focus on entrepreneurship, ventures creations and technology transfer. With these seminars we aim to gain insights into how to transform our research and ideas into a business.

An introduction article was recently published on the EUSynBioS Blog to bring forward some of the concepts that will be covered in the different panels and conversations during this series.

Our 2nd Entrepreneurship seminar, on Wednesday, February 24th, 18.00 CET, will be a conversation on Technology Transfer and Academia Spin-outs with Prof. Hagan Bayley (co-founder of Oxford Nanopores Technologies) and Marc Chevalier (Start-ups Manager at Pasteur Institute).
This event aims at giving you an intro on how to get your research out of the lab into a startup, and to glimpse into the experience of the guests into the challenges and potential of creating a startup from your work.

The registration for this event is open and you can participate by filling out the form here.

In the last EUSynBioSeminar of the year we are hosting Dr. Ana Zuniga, postdoctoral researcher at the Centre de Biochimie Structurale in Montpellier, France and Dr. Sarah Guiziou, postdoctoral researcher at the University of Washington, Seattle.

They will talk about their collaboration project titled "Logic circuit in living organism, from design to application" . The seminar will take place on Thursday, December 3rd, 17.00 Central European Time (GMT +1), via zoom

You can register here.

Update: Straight after the seminar, EUSynBioS President Huseyin Tas will be answering questions regarding the Steering Committee 2021 Application process!

Abstract:

Genetic programs operating in a history-dependent fashion are ubiquitous in nature and govern sophisticated processes such as development and differentiation. We developed a robust and scalable workflow for the implementation of history-dependent programs in living organisms by distributing the computational labor across a cellular population. Our design is based on standardized recombinase-driven DNA scaffolds expressing different genes according to the order of occurrence of inputs. Our integrated workflow offers a systematic implementation in living systems, due to its modularity and automated design. We are now applying these circuits to decode and recode lateral root development in plants and to engineer bacteria behavior for multiple purposes in human health. By sharing with you these preliminary data we want to demonstrate the wide range of applications that this technology can support when signal processing abilities are required.

In October’s EUSynBioSeminar we are hosting Dr. Pavel Dvořák, the head of the Microbial Bioengineering Laboratory at Masaryk University in Brno, Czech Republic. His work focuses on engineering interior and exterior of the emerging biotechnological chassis Pseudomonas putida toward bioprocessing of complex polymeric waste substrates.

His talk is entitled "Re-factoring interior and exterior of Pseudomonas putida for biotechnological processing of lignocellulosic substrates" and the seminar will take place on Thursday, October 29th, 16.00 Central European Time (GMT +1), via zoom

You can register here.

In August’s EUSynBioSeminar we are hosting Dr. Nico Claassens, Assistant Professor at the Laboratory of Microbiology, Wageningen University. He will present his work on entitled “A metabolic "xenotransplantation" : Replacing the Calvin Cycle with the Reductive Glycine Pathway in Cupriavidus necator”. The online seminar will take place on Thursday, August 20th 2020, at 16:00 CEST (GMT +2).

Registration is now open.

If you would like to participate in one of the monthly EUSynBioSeminars as a guest speaker, feel free to contact us.

In the next EUSynBioSeminar, Dr. Javier Santos Moreno from University of Lausanne will present his work on Multistable and dynamic CRISPRi-based synthetic circuits. The online seminar will take place on Thursday, July 23rd 2020, at 16:00 CEST (GMT +2).

Registration is now open.

If you would like to participate in one of the monthly EUSynBioSeminars as a guest speaker, feel free to contact us.