Join the next #EUSynbioSeminar and hear Morghan Lucas from the Centre for Genomic Regulation (CRG) give a talk titled "Exploring tRNAs and their modifications and crosstalk using Nano-tRNAseq, a nanopore RNA sequencing method"

Register here to join us the 27th of April at 16:00 CET

Join the next #EUSynbioSeminar on the 30th of March at 16:00 CET and hear Dr. Lewis Grozinger from the Polytechnic University of Madrid (UPM) give a talk titled "Multihost, multiplasmid genetic logic library: What happens in E.coli, stays in E.coli"

Register here to join us the 30th of March at 16:00 CET

Join us for our next EUSynbioSeminar and hear Iván Domenzain, from Jens Nielsen’s lab, speak about “In silico metabolic engineering for increased production of +100 chemicals in yeast cells, what have we learned?”

Register here to join us the 23rd of February at 16:00 CET

EUSynBioS seminars are back! Our first speaker of 2023 is CEO/Founder of BioFacation, Dr. Markus Schmidt.

Dr. Markus Schmidt has an interdisciplinary background in biomedical engineering, biology and technology assessment. He initiates and executes a number of projects dealing with responsible research and innovation in emerging science and technology areas, bringing together various stakeholders from science, regulation, industry, civil society and art. Markus’s talk is entitled ‘Biosaftey in synthetic biology: a genetic firewall metric’.

Register now here and join us on January 19th at 16:00 CET

For the last seminar of 2022,  Research Associate Dr. Eszter Csibra will present FPCountR, a tool that allows absolute fluorescent protein quantification for synthetic circuit characterisation. 

Register here to join us December 13th 16:00 CET

On the next EUSynbioSeminar, Dr. Uriel Urquiza-Garcia will speak about the simple bioware and software platform (PolyGEN) for automated design and fabrication of multiplexing sgRNA or crRNAs to be produced using RNA Pol-II promoters

Register here to join us October 27th 16:00 CET

In our new installment on genetic circuit engineering we welcome Shamal Withanage to discuss his work on the directed evolution of complex bacterial promoters. We'll hear about how he has been building genetic elements to advance our capabilities in the control of gene expression.

Register here to join us September 8th 2022 16:00 CET

Our next seminar speaker will be Dr. Klaudia Ciurkot. Klaudia did an industrial PhD at the Dutch biotech company DSM and University of Hamburg and in collaboration with University of Bristol.  Her PhD focused on synthetic biology and optimizing beta-carotene production using CRISPR toolbox. She is currently a Research Associate at Tom Ellis lab in Imperial College London, focusing on yeast engineering and developing CRISPR-based tools. For this seminar she will share with us her work on “Efficient multiplexed gene regulation in Saccharomyces cerevisiae using dCas12a”. 

Register here and join us on May 26th at 16:00 CET

Our next speaker of 2022 will be Dr. Fungmin (Eric) Liew, project manager at LanzaTech with his more recent work “Carbon-negative production of platform chemicals from industrial waste gases using engineered microbes”.

Register here and join us on April 28tht at 16:00 CET

In the next EUSynBioSeminar we are hosting Dr. Thomas E. Gorochowski, a Royal Society University Research Fellow based in the School of Biological Sciences at the University of Bristol, UK.

Thomas heads up the Biocompute Lab that focuses on better understanding the computational architecture of living systems with the goal of enabling the more efficient and rational reprogramming of biology to tackle problems spanning the sustainable production of adaptive living materials to the creation of new forms of cellular computer.

The online seminar will take place on Thursday, September 24th 2020, at 17:30 CEST (GMT +2) and you can register here.

Towards a complete and quantitative view of genetic circuit function - Abstract

Synthetic genetic circuits are composed of many interconnected parts that must function together in concert to implement desired biological computations. A major challenge when developing new circuits is that genetic parts often display unexpected changes in their performance when used in new ways. Such changes can arise due to contextual effects or unintended interactions with the host cell. In this talk, I will demonstrate how we have been using a variety of sequencing technologies to tackle problem. First, I will show how RNA-sequencing can be used to measure the function of every transcriptional part making up large genetic circuits. This enables us to better understand why some designs fail and helps pinpoint the root cause. Then, I will present some recent work where we combined RNA-sequencing with ribosome profiling and RNA spike-in standards to enable the first large-scale characterization of transcriptional and translational parts in absolute units. Finally, I will briefly discuss some new work that uses long-read nanopore sequencing to enable the characterization of thousands of genetic parts simultaneously to better understand their design constraints. Taken together, the methods presented provide a means for a more complete and quantitative view of the inner workings of genetic parts and circuits and improve our understanding of the rules governing the effective construction of larger and more complex biological systems.

After the first successful online EUSynBioSeminar in Mai, our series continues in June with two talks by postdoctoral fellows Shmuel Gleizer (Weizmann Institute of Science, Israel) and and Juntai Liu (University of Warwick).

Dr. Gleizer will present his work on engineering E. coli into an autotroph organism through metabolic rewiring and directed evolution (read more here), while Dr. Liu will guide us through the generation of chimeric photosystems to expand solar energy conversion beyond the natural boundaries of living systems (read more here and here).

The seminar will take place on Thursday, June 25th at 16:00 Central European Summer Time (CEST). Attendance is free of charge. To receive the zoom link, please register using the following link:

https://forms.gle/McDX1Z1EYEbedynU7

If you would like to participate in one of the monthly EUSynBioSeminars as a guest speaker, feel free to contact us.